Lene Uhrbom Selected Research

Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)

6/2022	Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas.
10/2014	Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.
6/2011	PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation.
12/2009	Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma.
9/2009	IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas.
9/2007	Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis.

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Lene Uhrbom Research Topics

Disease

25	Neoplasms (Cancer) 06/2022 - 10/2002
21	Glioma (Gliomas) 06/2022 - 10/2002
17	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 03/2005
7	Brain Neoplasms (Brain Tumor) 01/2019 - 08/2003
2	Oligodendroglioma 09/2009 - 11/2004
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Starvation 01/2017
1	Rupture 10/2014
1	Disease Progression 10/2014
1	Infections 09/2007
1	Leukemia 09/2007

Drug/Important Bio-Agent (IBA)

8	Platelet-Derived Growth FactorIBA 11/2018 - 08/2003
6	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 06/2022 - 09/2007
5	Pharmaceutical PreparationsIBA 01/2017 - 11/2013
4	NestinIBA 01/2020 - 10/2002
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2007
2	Transcription Factors (Transcription Factor)IBA 11/2019 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 09/2009
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 11/2018 - 11/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 12/2009
2	Glial Fibrillary Acidic ProteinIBA 01/2017 - 03/2005
2	Cyclin-Dependent Kinase Inhibitor p16IBA 10/2014 - 09/2009
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2011 - 08/2004
1	ChromatinIBA 01/2022
1	TransposasesIBA 01/2022
1	ParaffinIBA 12/2021
1	Formaldehyde (Formol)FDA Link 12/2021
1	Small Cytoplasmic RNAIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Aurora Kinase AIBA 11/2019
1	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 11/2018
1	NucleotidesIBA 01/2017
1	Amino Acids FDA Link 01/2017
1	Interleukin-8 (Interleukin 8)IBA 01/2017
1	Interleukin-10 (Interleukin 10)IBA 01/2017
1	Metalloproteases (Metalloproteinases)IBA 01/2017
1	Messenger RNA (mRNA)IBA 12/2016
1	pleiotrophin (HARP)IBA 12/2016
1	pterostilbeneIBA 11/2016
1	Plasminogen Activators (Plasminogen Activator)IBA 09/2015
1	Plasminogen Activator Inhibitor 1IBA 09/2015
1	Propofol (Diprivan)FDA LinkGeneric 02/2015
1	Ion Channels (Ion Channel)IBA 02/2015
1	Diazepam (Valium)FDA LinkGeneric 02/2015
1	Etomidate FDA LinkGeneric 02/2015
1	gamma-Aminobutyric Acid (GABA)IBA 02/2015
1	Protein Isoforms (Isoforms)IBA 02/2015
1	Adenosine Triphosphate (ATP)IBA 10/2014
1	vacquinol-1IBA 10/2014
1	CalciumIBA 01/2014
1	MicroRNAs (MicroRNA)IBA 08/2012
1	Becaplermin (PDGF-BB)FDA Link 08/2012
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 06/2011
1	Epidermal Growth Factor (EGF)IBA 06/2011
1	Chemokine CXCL12IBA 01/2011
1	Chemotactic FactorsIBA 01/2011
1	Stem Cell FactorIBA 01/2011
1	histidine-rich proteinsIBA 12/2009
1	Bevacizumab (Avastin)FDA Link 12/2009
1	Insulin-Like Growth Factor Binding Protein 2IBA 09/2009

Therapy/Procedure

9	Therapeutics 01/2018 - 11/2004
2	Transplantation 06/2022 - 06/2011
2	Drug Therapy (Chemotherapy) 01/2017 - 01/2017
1	Immunotherapy 01/2019